Running title: Mode of Action of Bacteriocins against MRSA Biofilm

Effects of bacteriocins on methicillin-resistant Staphylococcus aureus biofilm 1 2 Running title: Mode of Action of Bacteriocins against MRSA Biofilm 3 4 Ken-ichi Okuda, Takeshi Zendo, Shinya Sugimoto, Tadayuki Iwase, Akiko Tajima, 5 Satomi Yamada, Kenji Sonomoto, and Yoshimitsu Mizunoe 6 7 Department of Bacteriology, The Jikei University School of Medicine, Tokyo, Japan 8 Laboratory of Microbial Technology, Division of Applied Molecular Microbiology and 9 Biomass Chemistry, Department of Bioscience and Biotechnology, Faculty of 10 Agriculture, Graduate School, Kyushu University, Fukuoka, Japan 11 12 *Address correspondence to Ken-ichi Okuda, [email protected] and Yoshimitsu 13 Mizunoe, [email protected]. 14 15 AAC Accepts, published online ahead of print on 26 August 2013 Antimicrob. Agents Chemother. doi:10.1128/AAC.00888-13 Copyright © 2013, American Society for Microbiology. All Rights Reserved.